After a few weeks of working hard on it, myself and Patrick Galbraith have gotten DBD::drizzle working using the new libdrizzle.
Patrick is uploading it to CPAN right now, but you can get the latest version in my Launchpad tree. I have tested it running MogileFS as well, which seems to work perfectly.
For now its just a near direct port from libmysqlclient to libdrizzle.. but we are planning on revamping a few of the things to handle multiple connections and fully non-blocking I/O. w00t.